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《化学分析计量》 2019年第04期
DOI:10.3969/j.issn.1008-6145.2019.04.012
液相色谱-串联质谱法测定化妆品中的β-苔黑酚酸甲酯
黄日林1,张高旗2,陈意光1,王亚茹1,廖惠媚1,佘文勋1,郭旭东1,叶凌聪1
1.广州质量监督检测研究院,国家化妆品质量监督检验中心(广州),广州 511447; 2.佛山市质量计量监督检测中心,广东佛山 528225 
Determination of methyl atratate in cosmetics by liquid chromatography-tandem mass spectrometry
黄日林1,张高旗2,陈意光1,王亚茹1,廖惠媚1,佘文勋1,郭旭东1,叶凌聪1
1. Guangzhou Quality Supervision and Testing Institute, National Cosmetic Quality Supervision and Inspection Center (Guangzhou), Guangzhou 511447, China; 2. Foshan Supervision and Testing Center for Quality and Metrology, Foshan 528225, China 
摘要:建立水剂、乳液、膏霜、香波、油脂5种化妆品基质中β-苔黑酚酸甲酯的液相色谱-串联质谱测定方法。样品用甲醇提取,乳液和香波样品用弱阴离子小柱净化;用C18色谱柱分离,流动相为乙腈-水,梯度洗脱;质谱仪为电喷雾离子源-串联四级杆质谱;采用选择反应监测模式。β-苔黑酚酸甲酯的质量浓度在0.5~10 μg/L范围内与色谱峰面积呈良好的线性,线性相关系数(r2)为0.999,方法检出限为3 μg/kg,定量限为10 μg/kg。5种基质3个浓度水平平均加标回收率为83.0%~108%,测定结果的相对标准偏差为0.8%~7.3%(n=6)。方法快速、准确,适合化妆品中β-苔黑酚酸甲酯的测定。  
Abstract:A method for determining methyl-atratate in water, lotion, cream, shampoo and oil cosmetics by liquid chromatography-tandem mass spectrometry was established. Samples were extracted by methanol. Lotion and shampoo samples was cleaned by WAX cartridges. A C18 column was used for separation with acetonitrile-water as the mobile phase, gradient elution was selected. An electrospray-tandem quadrupole mass spectrometry and select reaction monitoring were used. The concentration of methyl atratate was linear with the chromatographic peak area in the range of 0.5-10 μg/L. The linear correlation coefficient(r2) was 0.999. The detection limit was 3 μg/kg and the quantification limit was 10 μg/kg. The meant recoveries in five matrixes at three concentration levels ranged from 83.0% to 108%. The relative standard deviations of detection results were 0.8%-7.3%(n=6). The method is accurate and quick, which is suitable for the determination of methyl atratate in cosmetics. 
关键词:β-苔黑酚酸甲酯;液相色谱-串联质谱法;化妆品 
Keywords:methyl atratate; liquid chromatography-tandem mass spectrometry; cosmetics 
本文引用格式:
黄日林,张高旗,陈意光,等.液相色谱-串联质谱法测定化妆品中的β-苔黑酚酸甲酯[J].化学分析计量,2019,28(4):53-56.
HUANG R L,ZHANG G Q,CHEN Y G,et al. Determination of methyl atratate in cosmetics by liquid chromatography-tandem mass spectrometry[J]. Chemical analysis and meterage,2019,28(4):53-56. 

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