碳纳米管修饰玻碳电极循环伏安法测定醋酸地塞米松
雷紫莹1,黄芹芹1,周清2,潘育方1
1.广东药科大学医药化工学院,广东中山 528458; 2.广东药科大学药学院,广州 510006
Determination of dexamethasone acetate by carbon nanotubes modified glassy carbon electrode-cyclic voltammetry
雷紫莹1,黄芹芹1,周清2,潘育方1
1. Department of Chemistry and Chemical Engineering Guangdong Pharmaceutical University, Zhongshan 528458, China; 2. Department of Pharmacy GuangDong Pharmaceutical University, Guangzhou 510006, China
摘要:建立了碳纳米管修饰玻碳电极循环伏安法测定醋酸地塞米松的方法。在pH值为 2.2的邻苯二甲酸氢钾-盐酸(KHP-HCl)缓冲溶液中,以经过1 mg/mL碳纳米管(CNTs)修饰的玻碳电极(GCE)为工作电极,采用循环伏安法扫描试样溶液,记录扫描图谱的峰电位和峰电流。醋酸地塞米松在0.85 V附近呈现较明显的氧化峰且浓度在8×10-6~7×10-4 mol/L范围内与峰电流呈良好的线性关系,相关系数为0.999 0,检出限为3.3×10-7 mol/L。用该方法测定护肤品中醋酸地塞米松的含量,在干扰物质共存的情况下的回收率为87.5%~116.3%,测定结果的相对标准偏差为1.8%~3.9%(n=5)。CNTs-GCE对醋酸地塞米松有较好的电化学响应,灵敏度较高,可应用于化妆品、药品中醋酸地塞米松的测定。
Abstract:The method for determination of dexamethasone acetate by carbon nanotubes modified glassy carbon electrode-cyclic voltammetry was established. In potassium acid phthalate-hydrochloric acid buffer solution (pH 2.2), a glassy carbon electrode which was modified by 1 mg/mL carbon nanotubes was used as working electrode, the solution was scanned by using cyclic voltammetry and the peak potential and current were recorded. Dexamethasone acetate showed a oxidation peak at 0.85 V, the peak current and concentration of dexamethasone acetate in the range of 8×10-6-7×10-4 mol/L showed a good linear relationship with correlation coefficient of 0.999 0 and the detection limit was 3.3×10-7 mol/L. This method was applied to determine dexamethasone acetate in face toner with the recoveries of 87.5%-116.3%, the relative standard deviation of determination results was 1.8%-3.9%(n=5) under the presence of interfering substances. The carbon nanotubes modified glassy carbon electrode show good response and high sensitivity for dexamethasone acetate, which could be applied to determination of dexamethasone acetate in cosmetics and pharmaceuticals.
关键词:醋酸地塞米松;玻碳电极;电化学;循环伏安法
Keywords:dexamethasone acetate; glassy carbon electrode; electrochemistry; cyclic voltammetry
基金:2016年国家级大学生创新创业训练计划项目(201610573015)
本文引用格式:
雷紫莹,黄芹芹,周清,等. 碳纳米管修饰玻碳电极循环伏安法测定醋酸地塞米松[J]. 化学分析计量,2018,27(1):23-26.
LEI Z Y,HUANG Q Q,ZHOU Q,et al. Determination of dexamethasone acetate by carbon nanotubes modified glassy carbon electrode- cyclic voltammetry[J]. Chemical analysis and meterage,2018,27(1):23-26.
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